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Pathways Recommended: Antibody-drug Conjugate/ADC Related
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immunomodulatory drugs

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123714
    TL4-12

    		MAP4K Apoptosis Inflammation/Immunology Cancer
    TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM) .
    TL4-12
  • HY-145886
    TLR7/8 antagonist 1

    		Toll-like Receptor (TLR) Infection Inflammation/Immunology Cancer
    TLR7/8 Antagonist 1 (Compound 16c) is the potent antagonist of TLR7/8 with IC50s of 3.91 and 2.19 μM, respectively. TLR7/8 Antagonist 1 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for researching infectious disease, cancer, and autoimmune disorders .
    TLR7/8 antagonist 1
  • HY-145885
    TLR7/8 agonist 6

    		Toll-like Receptor (TLR) Infection Inflammation/Immunology Cancer
    TLR7/8 agonist 6 (Compound 4) is the potent agonist of TLR7/8 with IC50s of 0.18 and 5.34 μM, respectively. TLR7/8 agonist 6 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for researching infectious disease, cancer, and autoimmune disorders .
    TLR7/8 agonist 6

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